Drug Isomer
Drug Isomer
Drug isomers are compounds with the same molecular formula but different atomic arrangements or spatial configurations. They are divided into structural isomers and stereoisomers, and have different biological activities, safety and metabolic characteristics. Drug isomers can be used as drug improvement groups or drug efficacy control groups. For example, Carvedilol has higher bioavailability and better safety than (R)-Carvedilol.
References:
- [1]. Evans AM, et al. Comparative pharmacology of S(+)-ibuprofen and (RS)-ibuprofen. Clin Rheumatol. 2001 Nov;20 Suppl 1:S9-14. [Content Brief]
- [2]. Andersson T. Single-isomer drugs: true therapeutic advances. Clin Pharmacokinet. 2004;43(5):279-85. [Content Brief]
- [3]. Chhabra N, et al. A review of drug isomerism and its significance. Int J Appl Basic Med Res. 2013 Jan;3(1):16-8. [Content Brief]
All Product Categories
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Drug Isomer Related Products (557)
Related Products (557)
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Methyl palmitoleate (Standard)
0 ImagesSynonyms: (Z)-Methyl hexadec-9-enoate (Standard); Methyl cis-9-Hexadecenoate (Standard)Methyl palmitoleate (Standard) is the analytical standard of Methyl palmitoleate. This product is intended for research and analytical applications. Methyl palmitoleate ((Z)-Methyl hexadec-9-enoate), a fatty acid methyl ester, is an analogue of Palmitoleate with cytoprotective and growth-promoting properties.
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(R,R)-Abacavir
0 ImagesCat. No.: HY-17423ICAS No.: 1443421-67-7(R,R)-Abacavir is the (R,R)-enantiomer of Abacavir (HY-17423). Abacavir is an orally active and competitive nucleoside reverse transcriptase inhibitor. Abacavir can inhibits the replication of HIV. Abacavir shows anticancer activity in prostate cancer cell lines. Abacavir can trespass the blood-brain-barrier and suppresses telomerase activity.
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(E)-MS0017509
0 ImagesCat. No.: HY-115847CAS No.: 124285-22-9(E)-MS0017509 is the E configuration of MS0017509. MS0017509 is a small molecule DNA damage repair inhibitor and radiosensitizer, primarily used in oncology research.
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(2S)-Monolaurin
0 ImagesCat. No.: HY-187069ACAS No.: 104266-02-6Synonyms: (2S)-1-Monolaurin(2S)-Monolaurin ((2S)-1-Monolaurin) is the S-enantiomer of Monolaurin (HY-121620) and is mirror-symmetrical to (2R)-Monolaurin (HY-187069).
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5-Fluoro PB-22 N-(4-fluoropentyl) isomer
0 ImagesCat. No.: HY-172045CAS No.: 2365471-15-25-Fluoro PB-22 N-(4-fluoropentyl) isomer is a structural isomer of 5-Fluoro PB-22.
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(E)-Antibacterial agent 210
0 ImagesCat. No.: HY-163508ACAS No.: 65937-49-7(E)-Antibacterial agent 210 is the isomer of Antibacterial agent 210 (HY-163508). Antibacterial agent 210 is a Pseudomonas aeruginosa quorum sensing inhibitor (QSI). Antibacterial agent 210 inhibits the quorum sensing systems by binding with LasR and PqsR, especially PqsR.
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(1R,2S,1'R)-Cypermethrin
0 ImagesCat. No.: HY-W152862CAS No.: 66841-24-5(1R,2S,1'R)-Cypermethrin is an isomer of Cypermethrin (HY-B0829). Cypermethrin is a Class II pyrethroid pesticide with oral activity and blood-brain barrier permeability.
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(S)-N-Nitrosoanatabine
0 ImagesCat. No.: HY-W653722CAS No.: 71267-22-6Synonyms: (S)-N-NAT; (S)-N'-Nitrosoanatabine(S) -N-Nitrosoanatabine ( (S) -N-NAT) is a potent carcinogen and biomarker of exposure to cigarette smoke. It′s found in a variety of tobacco products and oral snuff.
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(±)-(17S,18R)-Epoxyeicosatetraenoic acid
0 ImagesCat. No.: HY-113040BSynonyms: (±)-17(S),18(R)-EETeTr(±)-(17S,18R)-Epoxyeicosatetraenoic acid ((±)-17 (S),18 (R)-EETeTr) is one of the constituent enantiomers of (±) 17 (18)-EpETE. (±) 17 (18)-EpETE is an active metabolite of the ω-3 fatty acid eicosapentaenoic acid, and also an agonist of sphingosine-1-phosphate receptor 1 (S1P1).
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(-)-SA2572
0 ImagesCat. No.: HY-118968CAS No.: 112946-90-4(-)-SA2572 is an orally active Ca2+ inward channel inhibitor. (-)-SA2572 inhibits the slow Ca2+ inward channel and the fast Na+ inward channel. (-)-SA2572 inhibits depolarization-induced contraction of gastrointestinal smooth muscle and vascular smooth muscle, prolongs atrioventricular nodal conduction time, and inhibits His bundle-ventricular conduction time. (-)-SA2572 reduces systolic blood pressure in spontaneously hypertensive rats. (-)-SA2572 can be used in the research of hypertension.
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ent-Oseltamivir
0 ImagesCat. No.: HY-172515CAS No.: 1035895-88-5ent-Oseltamivir, the enantiomer of Oseltamivir (HY-13317), is a neuraminidase (NA) of influenza virus inhibitor. ent-Oseltamivir is promising for research of influenza virus infections.
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(-)-AGN 192403 hydrochloride
0 ImagesCat. No.: HY-182441CAS No.: 2568912-84-3Synonyms: (-)-BRD4780(-)-AGN 192403 ((-)-BRD4780) hydrochloride is the enantiomer of AGN 192403 hydrochloride (HY-101374A). AGN 192403 hydrochloride is a potent and selective imidazoline-1 receptor antagonist.
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(-)-Enitociclib (Standard)
0 ImagesCat. No.: HY-103019BRCAS No.: 1610408-96-2Synonyms: (R)-Enitociclib (Standard); (-)-BAY-1251152 (Standard); (-)-VIP152 (Standard)(-)-Enitociclib (Standard) is the analytical standard of (-)-Enitociclib (HY-103019B). This product is intended for research and analytical applications. (-)-Enitociclib ((R)-Enitociclib) is an enantiomer of Enitociclib (HY-103019E) with an optical rotation of (-). Enitociclib is a selective CDK9 inhibitor and apoptosis inducer. Enitociclib inhibits CDK9 activity and reduces the phosphorylation of Ser2 in the carboxyl-terminal domain (CTD) of RNA polymerase Pol II, thereby downregulating the transcription of key oncogenes such as MYC and MCL1. Enitociclib has anti-proliferative activity targeting MYC+ lymphoma and multiple myeloma (MM) cells, and has synergistic effects with Bortezomib (HY-10227) and Lenalidomide (HY-A0003), and can be used in the research of hematological malignancies.
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(S)-(-)-Nitrendipine
0 ImagesCat. No.: HY-W706573CAS No.: 80873-62-7Synonyms: (S)-(-)-BAY-E-5009(S)-(-)-Nitrendipine ((S)-(-)-BAY-E-5009) is an isomer of Nitrendipine (HY-B0424). Nitrendipine acts as a calcium channel blocker. (S)-(-)-Nitrendipine can be used for research on hypertension.
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(Rac)-GK563
0 ImagesCat. No.: HY-126072CAS No.: 1983928-04-6(Rac)-GK563 is the isomer of GK563 (HY-138990). GK563 is a Ca2+-independent group VI phospholipase A2 (GVIA iPLA2) inhibitor.
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2,3-MDA hydrochloride
0 ImagesCat. No.: HY-W743300CAS No.: 86029-48-32,3-MDA hydrochloride is a structural isomer of 3,4-Methylenedioxyamphetamine (MDA) which differs only in the placement of the methyledioxy group.
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PB-22 5-Hydroxyisoquinoline isomer
0 ImagesCat. No.: HY-172050CAS No.: 2365471-14-1PB-22 5-Hydroxyisoquinoline isomer is a structural isomer of PB-22. PB-22 is a cannabinoid.
